Buy Tildren for Horses indicated for the control of clinical signs associated with navicular syndrome in horses. It is a bisphosphonate drug for intravenous infusion. Each 30 ml vial contains a sterile powder of 500 mg tiludronic acid (as tiludronate disodium) and 250 mg mannitol USP. Buy Tildren for Horses Online from us at very competitive prices.Tildren is a prescription medication formulated to help horses control symptoms associated with navicular syndrome. This degenerative
condition typically causes pain in the heel of the horse’s front feet, where the navicular bone is located. Horses can experience pain from changes in the bones, tendons, ligaments and bursa—the joint structures that are filled with fluid.
This pain can result in lameness, which causes the horse to move abnormally by overcompensating for the affected area. Tildren helps to restore balance to the bone remodeling process, which replaces old bone tissue with new tissue.
Tildren is indicated for the control of clinical signs associated with navicular syndrome in horses. Navicular syndrome is the most common cause of chronic forelimb lameness in performance horses. It is a degenerative process instigated by mechanical forces. Buy Tildren Infusion.
Possible Side Effects
Do not use in horses with impaired renal function or with a history of renal disease. Bisphosphonates are excreted by the kidney; therefore, conditions causing renal impairment may increase plasma bisphosphonate concentrations resulting in an increased risk for adverse reactions. Do not use in horses with known hypersensitivity to tiludronate disodium or to mannitol.
Drug & Food Interactions
NSAIDs should not be used concurrently with Tildren. Concurrent use of NSAIDs with Tildren may increase the risk of renal toxicity and acute renal failure.
NSAIDs should not be used concurrently with Tildren. Concurrent use of NSAIDs with Tildren may increase the risk of renal toxicity and acute renal failure. The safe use of Tildren has not been evaluated in horses less than 4 years of age. Bisphosphonates should not be used in pregnant or lactating mares, or mares intended for breeding.
A single dose of Tildren should be administered as an intravenous infusion at a dose of 1 mg/kg (0.45 mg/lb). The infusion should be administered slowly and evenly over 90 minutes to minimize the risk of adverse reactions. Maximum effect may not occur until 2 months post-treatment.
Sterile powder (not reconstituted): Store at controlled room temperature 68-77° F (20-25° C). After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36-46° F (2-8° C) and protected from light.
Step 1: Preparation of the reconstituted solution (20 mg/mL). Tildren should be reconstituted using strict aseptic technique. Remove 25 mL of solution from a 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP and add it to one vial of Tildren. Shake gently until the powder is completely dissolved. This reconstituted solution contains 20 mg of tiludronate disodium per mL. After reconstitution further dilution is required before administration.
Step 2: Preparation of the solution for infusion. Using strict aseptic technique, withdraw the appropriate volume of the reconstituted solution based on the horse’s body weight (see Table 1 below). Inject that volume back into the 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP.
Horses greater than 1,210 lbs. will require a second vial of reconstituted Tildren solution. Invert the infusion bag to mix the solution before infusion.
Label the infusion bag to ensure proper use.After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36-46° F (2-8° C) and protected from light.
Step 3: Administer for infusion through a suitable intravenous catheter inserted into a jugular vein and connected to the infusion bag using sterile disposable infusion tubing.
Do not reconstitute or mix Tildren with calcium containing solutions or other solutions containing divalent cations such as Lactated Ringers as it may form complexes with these ions